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Simon A Jones Selected Research

Niemann-Pick Diseases (Niemann Pick Disease)

3/2023Correction : Long-term safety and clinical outcomes of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency: two-year results.
12/2022Long-term safety and clinical outcomes of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency: two-year results.
10/2022One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency.
1/2021One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency.
1/2021Changes in PCSK 9 and apolipoprotein B100 in Niemann-Pick disease after enzyme replacement therapy with olipudase alfa.
9/2020Clinical relevance of endpoints in clinical trials for acid sphingomyelinase deficiency enzyme replacement therapy.
1/2016Clearance of Hepatic Sphingomyelin by Olipudase Alfa Is Associated With Improvement in Lipid Profiles in Acid Sphingomyelinase Deficiency.
9/2015Successful within-patient dose escalation of olipudase alfa in acid sphingomyelinase deficiency.

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Simon A Jones Research Topics

Disease

35Inflammation (Inflammations)
01/2023 - 08/2003
20Mucopolysaccharidoses
04/2022 - 01/2011
15Mucopolysaccharidosis I (Hurler Syndrome)
10/2022 - 08/2011
15Arthritis (Polyarthritis)
01/2021 - 09/2003
11Mucopolysaccharidosis II (Hunter Syndrome)
11/2023 - 10/2010
10Infections
04/2024 - 11/2002
9Rheumatoid Arthritis
01/2020 - 05/2005
8Niemann-Pick Diseases (Niemann Pick Disease)
03/2023 - 09/2015
7Peritonitis
01/2023 - 11/2002
7Mucopolysaccharidosis III (Sanfilippo Syndrome)
12/2021 - 01/2011
7Neoplasms (Cancer)
12/2018 - 04/2005
6Wolman Disease (Wolman's Disease)
01/2023 - 11/2014
5Disease Progression
01/2018 - 08/2008
4Glycogen Storage Disease Type II (Pompe's Disease)
06/2023 - 01/2012
4Fibrosis (Cirrhosis)
01/2023 - 01/2014
4COVID-19
01/2022 - 01/2020
4Experimental Arthritis
01/2021 - 09/2003
4Chronic Disease (Chronic Diseases)
12/2018 - 09/2005
3Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
06/2023 - 08/2014
3Lysosomal Storage Diseases (Lysosomal Storage Disease)
04/2022 - 02/2015
3Gaucher Disease (Gaucher's Disease)
01/2022 - 12/2020
3Neurologic Manifestations (Neurological Manifestations)
01/2022 - 01/2016
3Neurodegenerative Diseases (Neurodegenerative Disease)
06/2015 - 01/2011
3Human Influenza (Influenza)
10/2013 - 02/2008
3Neuroinflammatory Diseases
10/2013 - 01/2012
2Fever (Fevers)
04/2024 - 01/2017
2Hemorrhage
04/2024 - 09/2020
2Persistent Infection
07/2023 - 12/2018
2Renal Insufficiency (Renal Failure)
01/2023 - 01/2018
2Type 2 Diabetes Mellitus (MODY)
01/2023 - 11/2017
2Necrosis
01/2023 - 01/2021
2Splenomegaly
12/2022 - 09/2020
2Cognitive Dysfunction
09/2022 - 09/2022
2Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
03/2022 - 01/2018
2Autoimmune Diseases (Autoimmune Disease)
01/2021 - 08/2014
2Critical Illness (Critically Ill)
12/2020 - 05/2020
2Metabolic Diseases (Metabolic Disease)
01/2020 - 05/2019
2Mucopolysaccharidosis VII (Sly Syndrome)
05/2019 - 01/2019
2Sleep Wake Disorders
01/2019 - 01/2019
2Dysostoses
01/2019 - 03/2016
2Mucopolysaccharidosis IV (Morquio Syndrome)
01/2019 - 03/2018
2Mitochondrial Diseases (Mitochondrial Disease)
12/2016 - 10/2016
2Hip Dislocation
03/2016 - 10/2013
2Tertiary Lymphoid Structures
02/2016 - 10/2015
2Lung Diseases (Lung Disease)
09/2015 - 07/2010

Drug/Important Bio-Agent (IBA)

33Interleukin-6 (Interleukin 6)IBA
01/2023 - 08/2003
22CytokinesIBA
01/2023 - 08/2003
16EnzymesIBA
06/2023 - 01/2011
10Proteins (Proteins, Gene)FDA Link
10/2022 - 08/2003
10Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
11/2014 - 09/2003
9GlycosaminoglycansIBA
04/2022 - 08/2011
9AntigensIBA
12/2018 - 05/2006
8idursulfaseFDA Link
11/2023 - 10/2010
8LipidsIBA
01/2023 - 08/2009
7olipudase alfaIBA
03/2023 - 09/2015
7ChemokinesIBA
11/2016 - 05/2004
5InterleukinsIBA
07/2023 - 01/2011
5Biomarkers (Surrogate Marker)IBA
01/2021 - 02/2015
4AcidsIBA
12/2022 - 01/2012
4Sebelipase alfaIBA
03/2021 - 11/2014
4AntibodiesIBA
06/2019 - 05/2006
4human GALNS proteinIBA
01/2018 - 11/2014
4Interleukin-10 (Interleukin 10)IBA
06/2016 - 08/2014
4Cytokine Receptor gp130IBA
01/2011 - 09/2003
3Anti-Bacterial Agents (Antibiotics)IBA
04/2024 - 11/2014
3N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA
06/2023 - 08/2014
3C-Reactive ProteinIBA
01/2023 - 09/2014
3Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
12/2022 - 09/2015
3Iduronidase (alpha-L-Iduronidase)IBA
10/2022 - 10/2015
3Interleukin-27 (Interleukin 27)IBA
01/2020 - 10/2015
3Matrix Metalloproteinases (MMPs)IBA
01/2014 - 01/2002
3N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA
10/2013 - 01/2011
2Triglycerides (Triacylglycerol)IBA
01/2023 - 11/2014
2LigandsIBA
01/2023 - 12/2011
2Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
01/2023 - 11/2014
2LDL CholesterolIBA
01/2023 - 01/2021
2Insulin (Novolin)FDA Link
01/2023 - 11/2017
2Macrophage Colony-Stimulating FactorIBA
01/2023 - 01/2013
2CholesterolIBA
01/2023 - 01/2018
2Lysergic Acid Diethylamide (LSD)IBA
01/2022 - 01/2019
2Glucosylceramidase (Glucocerebrosidase)IBA
01/2022 - 12/2020
2heparan sulfate sulfataseIBA
12/2021 - 01/2016
2neodymium pyrocatechin disulfonate (NPD)IBA
01/2021 - 09/2015
2Interleukin-17 (Interleukin 17)IBA
01/2020 - 10/2011
2InterferonsIBA
01/2020 - 01/2014
2vestronidase alfaIBA
05/2019 - 01/2019
2human GAA protein (Myozyme)FDA Link
07/2017 - 01/2012
2Antiviral Agents (Antivirals)IBA
04/2017 - 04/2014
2Mitochondrial DNA (mtDNA)IBA
12/2016 - 10/2016
2SphingomyelinsIBA
01/2016 - 09/2015

Therapy/Procedure

33Enzyme Replacement Therapy
03/2023 - 10/2010
21Therapeutics
01/2022 - 01/2002
10Hematopoietic Stem Cell Transplantation
01/2022 - 08/2011
4Peritoneal Dialysis
01/2023 - 12/2011
4Cell Transplantation
01/2023 - 03/2015
4Stem Cell Transplantation
01/2022 - 03/2016
3Artificial Respiration (Mechanical Ventilation)
12/2020 - 01/2011
2Biological Therapy
01/2022 - 03/2013
2Transplantation
01/2022 - 02/2016
2Mechanical Ventilators (Ventilator)
10/2016 - 01/2011